منابع مشابه
Truncated mu (mu') chains in murine IgM. Evidence that mu' chains lack variable regions
Secreted IgM was shown to contain truncated mu (mu') chains with an apparent molecular mass of approximately 55 kD. The estimated percentage of IgM heavy (H) chains in the mu' form ranged from less than or equal to 1% in the case of one tumor IgM protein (104E) to greater than or equal to 30% in normal serum IgM. Serum mu' chains lacked antigenic determinants characteristic of immunoglobulin va...
متن کاملShark Immunoglobulin Light Chains
The humoral adaptive immune system of sharks is partly based on the same H2L2 heterodimeric antibody structure seen in all jawed vertebrates (reviewed in Flajnik 2002). The constituent vertebrate immunoglobulin (Ig) heavy (H) and light (L) chains provide obligate defense against pathogens and their toxins via neutralization, opsonization, and activation of the classical pathway of the complemen...
متن کاملFeedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains [published erratum appears in J Exp Med 1989 Jun 1;169(6):2269]
Previous work (6-10) has shown that allelic exclusion of Ig gene expression is controlled by functionally rearranged mu and kappa genes. This report deals with the comparison of membrane mu (micron) and secreted mu (microsecond) in promoting such feedback inhibition. Splenic B cell hybridomas were analyzed from transgenic mice harboring a rearranged kappa gene alone or in combination with eithe...
متن کاملImmunoglobulin light (IgL) chains in ectothermic vertebrates.
Four major ancesteral IgL isotypes have been identified κ, λ, σ and σ-cart. However, depending on the vertebrate class the genomic representation of these isotypes differs in regards to what is encoded in the germline and how these genes are organized. Also, the relative contribution of each isotype in immune responses varies. This review focuses on the IgL chains of ectothermic vertebrates, sp...
متن کاملElectron Microscopy of Polyribosomes Synthesizing Immunoglobulin Chains
Polyribosomes from the immunoglobulin-producing plasma-cell tumour X5563 were fractionated on a linear sucrose gradient and fractions containing polyribosomes carrying heavy (H) and light (L) immunoglobulin chains were examined with the electron microscope. The size distribution of the polyribosomes in the various fractions was determined. The results are consistent with previous estimates by W...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1982
ISSN: 0261-4189
DOI: 10.1002/j.1460-2075.1982.tb01208.x